EZYDeep

Enzymes play a crucial role in numerous chemical processes that are essential for life. In this website, we present EZYDeep, a deep learning tool based on convolutional neural networks, for classifying enzymes based on their sequence information. The tool showed exceptional performance with accuracy rates over 95% at all four levels of prediction.

Input Sequence Requirements

1. The length of the input sequence should be between 50AA to 1500AA. Lines that contain '>' will be removed automatically; whitespace characters will be removed automatically.
2. The input sequence should not contain letters other than the 20 AA letters.

Sample Input

Here are some sample inputs. Phrases after '>' indicate the ground truth for that sequence.

>Non-enzyme
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>Non-enzyme
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKVTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSGSDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE

>1.1.1.100,Oxidoreductases,Acting on the CH-OH group of donors,With NAD or NADP as acceptor
MHYLPVAIVTGATRGIGKAICQKLFQKGLSCIILGSTKESIERTAIDRGQLQSGLSYQRQCAIAIDFKKWPHWLDYESYDGIEYFKDRPPLKQKYSTLFDPCNKWSNNERRYYVNLLINCAGLTQESLSVRTTASQIQDIMNVNFMSPVTMTNICIKYMMKSQRRWPELSGQSARPTIVNISSILHSGKMKVPGTSVYSASKAALSRFTEVLAAEMEPRNIRCFTISPGLVKGTDMIQNLPVEAKEMLERTIGASGTSAPAEIAEEVWSLYSRTALET

>2.7.4.13,Transferases,Transferring Phosphorus-Containing Groups,Phosphotransferases with a phosphate group as acceptor
MELIFLSGIKRSGKDTTADYINSNFKSIKYQLAYPIKDALAIAWERKHAENPDVFTELKYEYFEGIGYDRETPLNLNKLDVIELMEETLIYLQRQYLPINGVNILSSLEGGYSYLDIKPYEALREAINNINDTWSIRRLMQALGTDVVVNLFDRMYWVKLFALNYMDYIGSDFDYYVVTDTRQVHEMETARAMGATVIHVVRSGTESTDKHITEAGLPIEEGDLVITNDGSLEELYSKIEKILR

>3.4.21.53,Hydrolases,Peptidase,Serine proteases
MLARALIRRRQAVTTLAAPSRARSTRSRALLDELGAGAVAAEGVGRARGSSKNAFVRATTANGNETLASAGDGGSTSSASSSSTTSGGIMVSAAHPSSHPQVLAVPLPRRPLMPGIIMPVKVTDEKLIAELEDMRNRGQAYVGAFLMRSEGSSSSSAAGKEEDAFDALTKRTVASVGLDGEEEEGADPSDHMHDIGTFAQVHNIVRLPADSPNGEESATLLLLGHRRLRKLGTMKRDPLVVQVEHLKDEKFDANDDIIKATTNEVVATIKDLLKTNPLHKETLQYFAQNFNDFQDPPKLADLGASMCSADDAQLQRVLELLSVKDRLDATLELLKKEVEIGKLQADIGKKVEDKISGDQRRYFLMEQLKSIKKELGMERDDKTALIEKFTKRFEPKRKSVPEETVKVIDEELQKLSGLEPSSSEFNVTRNYLEWLTSLPWGVCGDEKLDIAHAQEVLDADHYGLEDVKDRILEFIAVGQLLGTTQGKIITMVGPPGVGKTSIGQSIAKALGRKFYRFSVGGMSDVAEIKGHRRTYVGAMPGKLIQCLKSTGVCNPVVLIDEIDKLGRGYQGDPASALLELLDPEQNGTFLDHYLDVPVDLSKVLFVCTANVLDTIPGPLLDRMEVVRLSGYITDEKVQIARTYLEKAAKGKSGLSDFDATITDEAMSKLIGDYCREAGVRNLQKHLEKVYRKVALKVARAKSTDTTLDPIVIDVDDLVDYVGQPPFQTDRIYDETPPGVVTGLAWTAMGGSTLYIECTSVESGEGKGSLKTTGQLGDVMKESSAIAHTFTRGFLQSKDPGNDFLQKTSLHVHVPAGATPKDGPSAGVTITTSLLSLAMDKPVKPNLAMTGELTLTGRVLPVGGIKEKTIAARRSGVKTIIFPQGNKKDYDELSEDIREGLEACFVSTYDEVYRHALDWDR